Disease-modifying therapies in amyotrophic lateral sclerosis
نویسندگان
چکیده
منابع مشابه
Amyotrophic Lateral Sclerosis in a Patient with Behçet’s Disease
Behçet’s disease is a multisystem vasculitis. Its neurological involvement mostly includes parenchymal and non-parenchymal central nervous system manifestations. Peripheral nervous system presentations are rare. A 32-yr-old male patient who fulfilled the international study group criteria for Behçet’s disease, referred to our center with walking difficulty and repeated falling downs. Neurologi...
متن کاملDisease-modifying and symptomatic treatment of amyotrophic lateral sclerosis
In this review, we summarize the most important recent developments in the treatment of amyotrophic lateral sclerosis (ALS). In terms of disease-modifying treatment options, several drugs such as dexpramipexole, pioglitazone, lithium, and many others have been tested in large multicenter trials, albeit with disappointing results. Therefore, riluzole remains the only directly disease-modifying d...
متن کاملAmyotrophic lateral sclerosis: from disease mechanisms to therapies.
Amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease is the most common motor neuron disease in human adults, described as early as 1869 by a French neurobiologist and physician, Jean-Martin Charcot. Although advances in genetics have accelerated the pace of ALS research in the past decade, there is currently only one FDA-approved compound (Riluzole) to treat the disease, a compound that...
متن کاملCell-based therapies for amyotrophic lateral sclerosis/motor neuron disease.
BACKGROUND Amyotrophic lateral sclerosis (ALS), which is also known as motor neuron disease (MND) is a fatal disease associated with rapidly progressive disability, for which no definitive treatment as yet exists. Current treatment regimens largely focus on relieving symptoms to improve the quality of life of those affected. Based on data from preclinical studies, cell-based therapy is a promis...
متن کاملRNA-Targeted Therapies and Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal motor disease in adults. Its pathophysiology remains mysterious, but tremendous advances have been made with the discovery of the most frequent mutations of its more common familial form linked to the C9ORF72 gene. Although most cases are still considered sporadic, these genetic mutations have revealed the role of RNA production, processing and tra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2020
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2020.107986